Quantitative proton magnetic resonance spectroscopy without water suppression

Proton Nuclear Magnetic Resonance Spectroscopy

Brain Proton Magnetic Resonance Spectroscopy

Magnetic resonance (MR) spectroscopy is an analytical method used in chemistry that enables the identification and quantification of metabolites in samples. It differs from conventionalMR imaging in that spectra provide physiologic and chemical information instead of anatomy. MR spectroscopy and MR imaging have their origin in nuclear magnetic resonance (NMR). NMR was first described in 1946 si...

Amyloid oligomer formation probed by water proton magnetic resonance spectroscopy.

Formation of amyloid oligomers, the most toxic species of amyloids in degenerative diseases, is critically coupled to the interplay with surrounding water. The hydrophobic force driving the oligomerization causes water removal from interfaces, changing the surface-hydration properties. Here, we show that such effects alter the magnetic relaxation response of local water in ways that may enable ...

Assessment of Cerebellar Metabolites Levels in Athletes Compared to Non-Athlete by Proton Magnetic Resonance Spectroscopy

Background: Adaptability to exercise training can increase the plasticity of the brain, and whether this can be due to a beneficial change in the neurometabolites, is uncertain. The purpose of this study was to evaluate basal metabolic concentrations of cerebellum, including N-acetyl aspartate (NAA) and Cholin(Cho) in athletes and compare them with non-athlete subjects. Materials and Methods: I...

Proton MR spectroscopic imaging without water suppression.

To improve reproducibility in proton magnetic resonance (MR) spectroscopic imaging in human brain, simultaneous acquisition of the internal water reference and metabolite signals was evaluated. Measurements in healthy volunteers showed that the increase in dynamic range from signal oversampling was sufficient to avoid digitization errors. In addition, use of singular value decomposition techniq...